Creating innovative health solutions for individuals and populations | MIT News

The factors impacting successful patient care are many and varied. Early diagnosis, proper adherence to prescription medication schedules, and effective monitoring and management of chronic disease, for example, all contribute to better outcomes. However, each of these factors can be hindered by outside influences — medication doesn’t work as well if it isn’t taken as prescribed, and disease can be missed or misdiagnosed in early stages if symptoms are mild or not present.

Giovanni Traverso, the Karl Van Tassel Career Development Professor, an associate professor of mechanical engineering, and a gastroenterologist in the Division of Gastroenterology, Brigham and Women’s Hospital (BWH), is working on a variety of innovative solutions to improve patient care. As a physician and an engineer, he brings a unique perspective.

“Bringing those two domains together is what really can help transform and accelerate our capacity to develop new biomedical devices or new therapies for a range of conditions,” he says. “As physicians, we’re extremely fortunate to be able to help individuals. As scientists and engineers, not only can we help individuals … we can help populations.”

Traverso found a passion for this work early in life. His family lived in his father’s native Peru through much of his childhood, but left in the late 1980s at the height of the nation’s political instability, emigrating to Canada, where he began high school.

“In high school, I had the incredible opportunity to actually spend time in a lab,” he says. “I really fell in love with molecular genetics. I loved the lab environment and that ability to investigate a very specific problem, with the hopes that those developments would eventually help people.”

He started medical school immediately after high school, attending the University of Cambridge, but paused his medical training to pursue a PhD in medical sciences at Johns Hopkins University before returning to Cambridge. After completing medical school, he completed internal medicine residency at BWH and his gastroenterology fellowship training at Massachusetts General Hospital, both at Harvard Medical School. For his postdoctoral research, he transitioned to the fields of chemical and biomedical engineering in the laboratory of Professor Robert Langer.

Traverso’s research interests today include biomedical device development, ingestible and implantable robotics, and drug delivery for optimal drug adherence. His academic home at MIT is in the Department of Mechanical Engineering, but his work integrates multiple domains, including mechanical engineering, electrical engineering, material science, and synthetic biology.

“The mechanical engineering department is a tremendous place to engage with students, as well as faculty, towards the development of the next generation of medical devices,” he says. “At the core of many of those medical devices are fundamental mechanical principles.”

Traverso’s team in the Laboratory for Translational Engineering is developing pioneering biomedical devices such as drug delivery systems to enable safe, efficient delivery of therapeutics, and novel diagnostic tests to support early detection of diseases.

The heart of his work, he says, is “about trying to help others. Patients, of course, but also students, to help them see the arc of bench-to-bedside and help stimulate their interest in careers applying engineering to help improve human health.”